Biomolecular Crystallography: Principles, Practice, and Application to Structural Biology by Bernhard Rupp combines a comprehensive coverage of the fundamentals with methodological details that are often omitted in introductory texts. It will be of value to anyone that works in macromolecular X-ray crystallography, particularly to graduate students or postdoctoral fellows who are mastering the technique.
Ever despaired as a practicing structural biologist turned crystallographer about texts that were either too technical, not technical enough, or did not have any relevance to how things are done in practice? It is a text written by experienced academic teacher with ample of routine in the grunt work of structure determination and analysis. Many applications and examples ranging from fundamental biochemical questions to structure based drug discovery.
Given the extraordinary progress in biomolecular crystallography, the challenge of providing a comprehensive and authoritative overview, starting from first principles, is formidable. Its 808 pages are beautifully written and wonderfully illustrated, many in color. This book will be an essential part of the library of any department that claims to make contributions to modern biology and a necessary addition also to the libraries of big pharmaceutical companies and small biotechs.
This is a book to be enjoyed by all who wish to become structural biologists. I am also sure that many practicing structural biologists - even some who consider themselves mature - would do well to read its pages. It is first and foremost a comprehensive reference text and laboratory manual for the practicing structural biologist, from the basics of biomolecular structure to modern advanced and powerful techniques in biomolecular structure determination, and analysis and application of structural information.
Figures and graphs computed from new and original data are used extensively to help clarify important concepts, and derivations of all relevant mathematical and statistical principles—many of which have never been brought together in a single volume—are presented.
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